Pulmonary Hypertension

Deep vein clots in critical COVID-19 illness - News-Medical.Net Deep vein clots in critical COVID-19 illness - News-Medical.Net Posted: 31 May 2020 08:09 PM PDT A new research paper published in the journal JAMA Network Open in May 2020 reports a high incidence of deep vein clots in patients with severe COVID-19 at a single French medical center. This could indicate the need for systematic anticoagulant therapy in these patients as a preventive measure. The pandemic of COVID-19 that is circulating the world, causing casualties by the hundreds of thousands, and millions of admissions, is the result of infection by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is mostly asymptomatic but can cause pneumonia and acute respiratory distress syndrome (ARDS) in a significant minority of patients. COVID-19 and Clots The most common cause of death is ARDS; however, organs other than the lungs ar...

Pittsburgh Rare Disease Community Transitions Beloved Event to Virtual - PR Web Pittsburgh Rare Disease Community Transitions Beloved Event to Virtual - PR Web Posted: 29 May 2020 01:33 PM PDT This event means a great deal to hundreds of people. As such, we are dedicated to taking the necessary precautions in order to provide a safe atmosphere and ensure this event can go on successfully. PITTSBURGH (PRWEB) May 29, 2020 Seven years ago, volunteers in Pittsburgh began preparations for a 5K to support nonprofit Team PHenomenal Hope's mission to end a rare lung disease, pulmonary hypertension (PH). Due to the COVID-19 pandemic, things may be vastly different this year, but that won't prevent the PH community from participating virtually in the PHenomenal Hope 5K starting on Saturday, June 27. PH is a rare disease that causes high blood pressure in the arteries of the lungs, which puts unnecessary stress on both the ...

PAH Development May Be Boosted by Epigenetic Changes, Study Reports - Pulmonary Hypertension News PAH Development May Be Boosted by Epigenetic Changes, Study Reports - Pulmonary Hypertension News Posted: 29 May 2020 09:00 AM PDT Changes in the epigenetic profile — a collection of marks that turn genes on and off  — of pulmonary arterial endothelial cells from people with pulmonary arterial hypertension (PAH) may contribute to disease development, a study suggests. The study, " Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension , " was published in the journal Nature Communications . PAH is considered a multifactorial disease, meaning its cause is not only associated with genetic DNA variations but also with environmental cues that influence the cells' epigenetic profile, which are external modifications to DNA ...

COVID-19 Likely to Delay Rare Disease and Gene Therapy Trials - Pulmonary Hypertension News COVID-19 Likely to Delay Rare Disease and Gene Therapy Trials - Pulmonary Hypertension News Posted: 28 May 2020 08:45 AM PDT While the ongoing COVID-19 pandemic won't have much of an impact on cash available for new biotech startups, it has begun to cause delays in the development of gene therapies to treat a variety of rare diseases. That's the consensus of industry experts who spoke in a May 26 webinar hosted by the events organizer Terrapinn , producer of the annual World Orphan Drug Congress . Denise Cloutier, lab manager at the University of Florida's Powell Gene Therapy Center, prepares a DNA sample for testing. (Photo by Larry Luxner) The one-hour event featured Sander van Deventer, executive vice president of research and product development at Amsterdam-based uniQure , and an operating partner at Forb...