Pulmonary arterial hypertension is incurable but animal model study suggests an experimental drug may be effective - Medical Xpress
+/- mice. a: SM22-Cre mice were bred with Tsc2 flox/flox mice to generate SM22-Tsc +/- mice. b: Immunohistochemical analysis of lung tissue sections of SM22-Tsc2 +/- mice to detect TSC2 (red), smooth muscle α-actin (SMA) (green), and DAPI (blue). Representative images from n=5 WT and 7 SM22-Tsc2 +/- mice and 5 PAs/mouse. Scale bar, 30μm. Credit: Science Signaling (2022). DOI: 10.1126/scisignal.abn2743"> TCS2 protein reduction in SMA-positive areas in small PAs from SM22-Tsc +/- mice. a: SM22-Cre mice were bred with Tsc2 flox/flox mice to generate SM22-Tsc +/- mice. b: Immunohistochemical analysis of lung tissue sections of SM22-Tsc2 +/- mice to detect TSC2 (red), smooth muscle α-actin (SMA) (green), and DAPI (blue). Representative images from n=5 WT and 7 SM22-Tsc2 +/- mice and 5 PAs/mouse. Scale bar, 30μm. Credit: Science Signaling (2022). DOI: 10.1126/scisignal.abn2743 An ex...