Posts

Showing posts from August, 2024

Pregnancy and your heart: why it's important to plan ahead

Image
sarcoidosis restrictive lung disease :: Article Creator Immunosuppressive Therapy For Recurrent Ventricular Arrhythmias In Cardiac Sarcoidosis Photo Credit: Wildpixel The following is a summary of "Cardiac sarcoidosis in patients with recurrent ventricular arrhythmias refractory to endocardial ablation," published in the August 2024 issue of Cardiology by Nentwich et al. Cardiac sarcoidosis diagnosis is challenging due to diverse symptoms and potential sampling errors in endomyocardial biopsy (EMB), but early immunosuppression can improve prognosis. Researchers conducted a retrospective study investigating additional markers supporting the diagnosis of cardiac sarcoidosis by analyzing the single-center cohort of patients with recurrent ventricular arrhythmias (VA) and nonischemic cardiomyopathy after the failure of endocardial ablation. They analyzed data from 135 patients (mean age 49 y, 63% male) hospitalized for epicardial V...

Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

Image
pe pulmonary hypertension :: Article Creator Mean Pulmonary Artery Pressure Over Cardiac Output Slope And HFpEF Characteristics About 1 in 5 patients with unexplained dyspnea have pulmonary hypertension despite a negative diastolic stress test (DST), researchers reported in the Journal of the American Heart Association. The prospective cohort study assessed the prevalence and clinical significance of pulmonary hypertension during exercise (exPHT), based on the slope of estimated mean pulmonary arterial pressure over cardiac output (mPAP/CO) and its association with DST in patients with suspected heart failure with preserved ejection fraction (HFpEF). The participants were referred to a dyspnea clinic in Belgium from January 2016 to December 2022 owing to exertional dyspnea or fatigue and had available mPAP/CO slope data. The patients were stratified into 3 groups: exE/e′ of 15 or higher or a positive DST exE/e′ of less than 15 with exPHT d...

5 Things We Now Know About Pulmonary Arterial Hypertension

Image
hiv lung infection :: Article Creator What Are The Signs And Symptoms Of HIV And AIDS (stage 3 HIV)? The early signs and symptoms of HIV infection tend to be nonspecific. Within days or weeks of exposure to the virus, a person may notice flu-like symptoms, a rash, and fatigue. Some people may not have any symptoms. A person's symptoms may vary depending on their stage of progression. For example, someone with stage 1 HIV may have different symptoms from someone with stage 3 HIV, also known as AIDS. There are three stages of HIV. Below are the potential signs and symptoms of HIV depending on the stage of the condition: Stage 1 HIV symptoms Stage 1 HIV typically develops within 2 to 4 weeks of HIV transmission. Symptoms at this stage are often vague and unspecific, and may include: Early symptoms are usually bearable and frequently mistaken for the flu or another mild condition. People may easily underestimate them or ...

Pulmonary Hypertension in Congenital Heart Disease: A Scientific Statement From the American Heart Association

Image
apical lung cancer :: Article Creator FDA Approves New Treatment For Non-Small-Cell Lung Cancer Aug. 21, 2024 – The FDA has approved a new initial treatment for advanced non-small-cell lung cancer after clinical trials showed patients lived longer without disease progression, compared to the standard treatment currently used.  The chemotherapy-free combination involves two drugs, one of which has never been approved for use in the U.S. Called lazertinib, which will be marketed under the brand name Lazcluze. The other half is the drug amivantamab-vmjw, which is marketed under the brand name Rybrevant. Rybrevant was approved by the FDA in 2021. The new combined Lazcluze-Rybrevant therapy is now FDA-approved for adults with certain types of non-small-cell lung cancer that has progressed to stage III or stage IV, also called locally advanced and metastatic. Changes in a gene's DNA sequence drive the transformation of healthy cells into cancero...

Congenital heart disease in adults - Symptoms and causes

Image
lung obstruction :: Article Creator Improved Lung Function In Sickle Cell Disease Sickle cell disease is an inherited red blood cell disorder that affects hemoglobin, the protein carrying oxygen through the body. In this condition, red blood cells become sickle-shaped due to a genetic mutation, leading to obstruction in blood flow. Damage to lung tissue and poor lung function are important complications and the greatest cause of death in patients with sickle cell disease. A new study published in the Annals of the American Thoracic Society investigates whether less intensive types of transplants, generally better tolerated by many adults, cause subsequent lung damage. 'Low-intensity #blood #stem_cell_transplants improve #lung_health in adults with #sickle_cell disease. #medindia' Low-intensity blood stem cell transplants also known as non-myeloablative transplants, which use milder conditioning agents than standard stem cell t...

Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

Image
pda pulmonary hypertension :: Article Creator Mean Pulmonary Artery Pressure Over Cardiac Output Slope And HFpEF Characteristics About 1 in 5 patients with unexplained dyspnea have pulmonary hypertension despite a negative diastolic stress test (DST), researchers reported in the Journal of the American Heart Association. The prospective cohort study assessed the prevalence and clinical significance of pulmonary hypertension during exercise (exPHT), based on the slope of estimated mean pulmonary arterial pressure over cardiac output (mPAP/CO) and its association with DST in patients with suspected heart failure with preserved ejection fraction (HFpEF). The participants were referred to a dyspnea clinic in Belgium from January 2016 to December 2022 owing to exertional dyspnea or fatigue and had available mPAP/CO slope data. The patients were stratified into 3 groups: exE/e′ of 15 or higher or a positive DST exE/e′ of less than 15 with exPHT ...

Pulmonary Hypertension in Congenital Heart Disease: A Scientific Statement From the American Heart Association

Image
if you have high blood pressure :: Article Creator The #1 Thing To Avoid If You Have High Blood Pressure, According To Dietitians If you have hypertension, your doctor may have recommended lifestyle changes to bring down your levels. Don't overlook this very important one. Reviewed by Dietitian Emily Lachtrupp, M.S., RDReviewed by Dietitian Emily Lachtrupp, M.S., RD If you know you have high blood pressure, you're already ahead. Although high blood pressure (hypertension) affects nearly half of American adults, the condition doesn't initially cause symptoms, so many people do not know they have it. Read on to learn more about what high blood pressure is, the most important thing you should avoid doing if you have it, plus other strategies you can take to improve it. Related: The #1 Diet to Lower High Blood Pressure, According to Science What Is High Blood Pressure? Your blood pressure is the force of blood pushing through ...