Pulmonary Hypertension

Altavant Sciences Initiates Phase 2a Study of Rodatristat Ethyl in Pulmonary Arterial Hypertension - BioSpace Altavant Sciences Initiates Phase 2a Study of Rodatristat Ethyl in Pulmonary Arterial Hypertension - BioSpace Posted: 05 Aug 2019 12:00 AM PDT   CARY, N.C. and BASEL, Switzerland , Aug. 5, 2019 /PRNewswire/ -- Altavant Sciences , a clinical-stage biopharmaceutical company focused on patient-centric drug development in rare respiratory diseases, announced that it has dosed the first patient in the ELEVATE 1 proof-of-concept Phase 2a study of the company's lead candidate, rodatristat ethyl, in patients with pulmonary arterial hypertension (PAH). The study is designed to provide valuable safety, target engagement and biomarker information, which will be used to inform a comprehensive Phase 2b efficacy study of rodatristat ethyl in PAH. "Initiating the ELEVATE 1 Study is a significant milestone for Altavant, and represents o...

Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Posted: 30 Aug 2019 05:00 AM PDT Lung inflammation caused by a seemingly treatable and common infection may drive the onset of pulmonary arterial hypertension (PAH) in people who carry genetic risk factors for the disease. A simple viral infection — such as a bad flu — was able to trigger PAH development in rats with a mutation in the Bmpr2 gene, a known genetic risk factor for PAH, Stanford researchers report. "It's a kind of one-two punch [mechanism]. Basically, the first hit is the mutation, and the second hit is inflammation in the arteries of the lungs. You can be healthy and carrying this mutation, and all of the sudden you get a bacterial or viral infection,...

Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Posted: 30 Aug 2019 05:00 AM PDT Lung inflammation caused by a seemingly treatable and common infection may drive the onset of pulmonary arterial hypertension (PAH) in people who carry genetic risk factors for the disease. A simple viral infection — such as a bad flu — was able to trigger PAH development in rats with a mutation in the Bmpr2 gene, a known genetic risk factor for PAH, Stanford researchers report. "It's a kind of one-two punch [mechanism]. Basically, the first hit is the mutation, and the second hit is inflammation in the arteries of the lungs. You can be healthy and carrying this mutation, and all of the sudden you get a bacterial or viral infection,...

Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Posted: 30 Aug 2019 05:00 AM PDT Lung inflammation caused by a seemingly treatable and common infection may drive the onset of pulmonary arterial hypertension (PAH) in people who carry genetic risk factors for the disease. A simple viral infection — such as a bad flu — was able to trigger PAH development in rats with a mutation in the Bmpr2 gene, a known genetic risk factor for PAH, Stanford researchers report. "It's a kind of one-two punch [mechanism]. Basically, the first hit is the mutation, and the second hit is inflammation in the arteries of the lungs. You can be healthy and carrying this mutation, and all of the sudden you get a bacterial or viral infection,...

Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Posted: 30 Aug 2019 05:00 AM PDT Lung inflammation caused by a seemingly treatable and common infection may drive the onset of pulmonary arterial hypertension (PAH) in people who carry genetic risk factors for the disease. A simple viral infection — such as a bad flu — was able to trigger PAH development in rats with a mutation in the Bmpr2 gene, a known genetic risk factor for PAH, Stanford researchers report. "It's a kind of one-two punch [mechanism]. Basically, the first hit is the mutation, and the second hit is inflammation in the arteries of the lungs. You can be healthy and carrying this mutation, and all of the sudden you get a bacterial or viral infection,...

Inflammation in the lungs triggers silent mutation to cause pulmonary hypertension - News-Medical.net Inflammation in the lungs triggers silent mutation to cause pulmonary hypertension - News-Medical.net Comon Lung Infections May Trigger PAH in People with At-risk Mutations, Rat Study Finds - Pulmonary Hypertension News Planning Happy Moments to Drive Away the PH Storms - Pulmonary Hypertension News Inflammation in the lungs triggers silent mutation to cause pulmonary hypertension - News-Medical.net Posted: 29 Aug 2019 11:23 AM PDT Researchers at the Stanford University School of Medicine have found that inflammation in the lungs of rats, triggered by something as simple as the flu, may wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension, a deadly form of high blood pressure in the lungs. It's a kind of one-two punch. Basically, the first hit is the mutation, and the second hit...

Inflammation in the lungs triggers silent mutation to cause pulmonary hypertension - News-Medical.net Inflammation in the lungs triggers silent mutation to cause pulmonary hypertension - News-Medical.net Posted: 29 Aug 2019 11:23 AM PDT Researchers at the Stanford University School of Medicine have found that inflammation in the lungs of rats, triggered by something as simple as the flu, may wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension, a deadly form of high blood pressure in the lungs. It's a kind of one-two punch. Basically, the first hit is the mutation, and the second hit is inflammation in the arteries of the lungs. You can be healthy and carrying this mutation, and all of the sudden you get a bacterial or viral infection, and it leads to this terrible disease. " Amy Tian, PhD, senior research scientist in pulmonary and critical care Tian is the lead author of the study, which...