Pulmonary Hypertension

Treprostinil Approved to Delay Disease Progression in PAH - Pulmonology Advisor Treprostinil Approved to Delay Disease Progression in PAH - Pulmonology Advisor Posted: 23 Oct 2019 07:30 AM PDT The Food and Drug Administration (FDA) has approved the supplemental New Drug Application (sNDA) for Orenitram (treprostinil; United Therapeutics ) extended-release tablets for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to delay disease progression, in addition to improving exercise capacity.  The approval was based on data from the phase 3, multicenter, double-blind, placebo-controlled, FREEDOM-EV study that evaluated the effect of Orenitram on the progression of PAH in 690 patients receiving background PAH monotherapy (PDE-5 inhibitor, endothelin receptor antagonist or soluble guanylate cyclase stimulator). Patients were randomized 1:1 to receive 3 daily doses of Orenitram or placebo. The primary end point was the time to...

Respiratory diseases linked with high blood pressure in lungs: MU researcher examines underlying conditions causing pulmonary hypertension - Science Daily Respiratory diseases linked with high blood pressure in lungs: MU researcher examines underlying conditions causing pulmonary hypertension - Science Daily Posted: 16 Oct 2019 12:00 AM PDT Pulmonary hypertension is a type of high blood pressure that affects the lungs of both animals and people. When tiny vessels in the lungs become narrowed or blocked, it becomes harder for blood to flow through and can cause the heart to weaken or fail. Now, researchers at the University of Missouri have found that identifying respiratory diseases causing pulmonary hypertension can lead to improved health outcomes. Carol Reinero, professor of small animal internal medicine in the College of Veterinary Medicine, was a member of a team that studied 47 dogs with pulmonary hypertension caused by respiratory ...

How Diet Can Support PH Patients: A Nutritionist's View - Pulmonary Hypertension News How Diet Can Support PH Patients: A Nutritionist's View - Pulmonary Hypertension News Posted: 15 Oct 2019 12:00 AM PDT The mechanics of pulmonary hypertension (P H) create a cascade of events that affect the cardiovascular system, kidneys, respiratory system, and digestive system.  Though symptoms , which persist over time, primarily lead to changes in breathing and aerobic endurance, the lack of blood flow, extra exertion, hormone fluctuations, and inflammation caused by the disease have an effect on the entire holistic body. These issues can lead to obesity in adults, heart disease, and low birth weight in infants. Disease progression and current pharmacological treatment protocol in P H involves and affects many mechanisms that may influence nutritional status and induce muscle wasting and dec...

Bayer Announces Recipients of the Pulmonary Hypertension Accelerated Bayer (PHAB) Awards at CHEST Annual Meeting 2019 - BioSpace Bayer Announces Recipients of the Pulmonary Hypertension Accelerated Bayer (PHAB) Awards at CHEST Annual Meeting 2019 - BioSpace Posted: 21 Oct 2019 12:00 AM PDT   WHIPPANY, N.J. , Oct. 21, 2019 /PRNewswire/ -- Bayer today announced recipients of the inaugural Pulmonary Hypertension Accelerated Bayer (PHAB) Awards, a U.S.-based research grant program created to support clinical research in pulmonary hypertension (PH), with a focus on pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The recipients will receive a combined total of $1 million in grants over a two-year period, making the PHAB Awards one of the largest industry-funded grant programs focused on PAH and CTEPH in the U.S. The eight award recipients were formally announced at a ceremony during the American ...

Respiratory diseases linked with high blood pressure in lungs: MU researcher examines underlying conditions causing pulmonary hypertension - Science Daily Respiratory diseases linked with high blood pressure in lungs: MU researcher examines underlying conditions causing pulmonary hypertension - Science Daily Posted: 16 Oct 2019 11:00 AM PDT Pulmonary hypertension is a type of high blood pressure that affects the lungs of both animals and people. When tiny vessels in the lungs become narrowed or blocked, it becomes harder for blood to flow through and can cause the heart to weaken or fail. Now, researchers at the University of Missouri have found that identifying respiratory diseases causing pulmonary hypertension can lead to improved health outcomes. Carol Reinero, professor of small animal internal medicine in the College of Veterinary Medicine, was a member of a team that studied 47 dogs with pulmonary hypertension caused by respiratory ...

HMGB1 Protein May Be Biomarker of PPHN, Chinese Study Suggests - Pulmonary Hypertension News HMGB1 Protein May Be Biomarker of PPHN, Chinese Study Suggests - Pulmonary Hypertension News Posted: 10 Oct 2019 12:00 AM PDT Measuring the levels of an inflammatory protein known as HMGB1 may help diagnose persistent pulmonary hypertension of the newborn (PPHN) and monitor its progression, according to a study in patients and in a rat model. The research, " High mobility group box 1 protein (HMGB1) as biomarker in hypoxia-induced persistent pulmonary hypertension of the newborn: a clinical and  in vivo  pilot study ," was published in the International Journal of Medical Sciences . Asphyxia (oxygen deprivation) during the perinatal period may result in PPHN, characterized by increased blood pressure in the lungs after birth, and damage in the brain and other organs. Along with inflammatory factors such ...