DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension - Science Advances
DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension - Science Advances DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension - Science Advances Posted: 09 Dec 2020 11:30 AM PST Abstract DNA methylation plays critical roles in vascular pathology of pulmonary hypertension (PH). The underlying mechanism, however, remains undetermined. Here, we demonstrate that global DNA methylation was elevated in the lungs of PH rat models after monocrotaline administration or hypobaric hypoxia exposure. We showed that DNA methyltransferase 3B (DNMT3B) was up-regulated in both PH patients and rodent models. Furthermore, Dnmt3b −/− rats exhibited more severe pulmonary vascular remodeling. Consistently, inhibition of DNMT3B promoted proliferation/migration of pulmonary artery smooth muscle cells (PASMCs) in response to platelet-derived growth factor–BB (PDGF-BB). In c...