Pulmonary Hypertension

enlarged right pulmonary artery :: Article Creator Mitral Stenosis - Diagnosis The ECG in mitral stenosis is often normal early in disease. The most common finding is left atrial enlargement (p-mitrale), however this finding disappears if the patient enters atrial fibrillation. Right heart strain may produce findings of right axis deviation and right ventricular hypertrophy on ECG. In pure mitral stenosis, left ventricular hypertrophy would be absent. The chest radiograph will again show left atrial enlargement. This finding is often referred to as a "double density". Elevation of the left mainstem bronchus and a prominent pulmonary artery may also be seen. Both the ECG and the chest radiograph, however, are non-specific for mitral stenosis. Echocardiography is the primary means to both diagnose and evaluate the severity of MS. Since transmitral velocities can be determined, the transmitral pressur...

pulmonary arterial hypertension cardiovascular disease :: Article Creator Integrin α5β1 Is Target For Pulmonary Arterial Hypertension Cardiovascular Researchers from Morphic Therapeutic Inc. And affiliated organizations published data from a study that aimed to assess the potential of using arginylglycylaspartic acid (RGD) integrins for the treatment of cardiovascular diseases, such as pulmonary arterial hypertension (PAH). BioWorld Science Cardiovascular Macrophages More Inflammatory In Males With PAH Than Females Males with pulmonary arterial hypertension (PAH) have more proinflammatory macrophages — a type of immune cell — in the lungs than do females with the disease, a study suggests. Researchers identified 56 genes showing differing activity in macrophages taken from men and women with PAH, with this altered activity mainly taking place in a pathway thought to be involved in cell proliferation. Lowering the expression (activi...

left ventricular ejection fraction :: Article Creator Bayer Seeks Japanese Marketing Approval For Finerenone To Treat Adult Patients With Chronic Heart Failure Bayer announced the submission of a marketing authorization application to the Ministry of Health, Labour, and Welfare (MHLW) in Japan, seeking approval of finerenone in adult patients with chronic heart failure (with a left ventricular ejection fraction (LVEF) of =40%, i.E. Mildly reduced LVEF (HFmrEF) or preserved LVEF (HFpEF)). Finerenone is a non-steroidal, selective mineralocorticoid receptor antagonist (nsMRA) and the first drug targeting the mineralocorticoid receptor (MR) pathway that has demonstrated cardiovascular benefits in patients with HF with a left ventricular ejection fraction (LVEF) of =40% in a phase III study (FINEARTS-HF). Finerenone is already marketed as Kerendia or, in some countries, as Firialta, and approved for the treatment of adult patients with chronic kidney dis...

pulmonary hypertension due to sleep apnea :: Article Creator STAT6 Protein May Have Role In PH Tied To Sleep Apnea, Study Finds Activation of an immune signaling molecule called STAT6 may lead to pulmonary hypertension (PH) in people with oxygen deprivation due to obstructive sleep apnea, according to a recent study in mice. Obstructive sleep apnea is a common sleep disorder characterized by chronic intermittent hypoxia, or repeated episodes of stopping and starting to breathe while asleep. In the study, STAT6 levels were elevated in the lungs of a mouse model of intermittent hypoxia-induced PH. Deleting the protein eased disease severity in the mice and reduced signaling of an immune pathway called the Th2 response that's seen to be a driver of PH. "These findings exhibit the critical role of STAT6 in the pathogenesis [development] of CIH [chronic intermittent hypoxia] induced PH by regulating Th2 immune response," the researc...

diastolic hypertension causes :: Article Creator Diastole Vs. Systole: Know Your Blood Pressure Numbers When you check your blood pressure, you get two numbers. The first, or top, number, is called systolic blood pressure. The second, or bottom, number is called diastolic blood pressure. These two numbers show how hard your heart works to pump blood throughout your body and how much pressure it puts on your blood vessels. If one or both numbers consistently stay too high, it's called hypertension. It can damage your organs over time and lead to serious health problems. The difference between systolic pressure and diastolic pressure is that they reflect two different forces during one heartbeat: Systolic pressure. This is the force against your arteries as your heart squeezes to pump out blood. It's a snapshot of how hard your heart is pumping at that moment Diastolic pressure. This is the pressure in your arteries as your heart res...

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pulmonary copd :: Article Creator Study: Mindfulness Helps People With COPD Manage Anxiety, Breathlessness, Insomnia BUFFALO, N.Y. – University at Buffalo School of Nursing researchers have identified a new benefit of mindfulness for people managing chronic obstructive pulmonary disease, a condition commonly known as COPD. The study, "Associations Between Mindfulness and Symptom Severity among Adults Living with Chronic Obstructive Pulmonary Disease (COPD)," was published in the December 2024 issue of Heart & Lung: The Journal of Cardiopulmonary and Acute Care. Led by Tania T. Von Visger, PhD, and Yu-Ping Chang, PhD, the study surveyed 339 adults with COPD. Participants who practice mindfulness reported significantly less severe symptoms of anxiety, breathlessness, fatigue and insomnia. Also, a substantially lower anxiety score was found for participants who practice mindfulness, but not for those who only know about mindfulness,...