Specific gut bacteria may be associated with pulmonary arterial hypertension - Science Daily

Posted: 24 Feb 2020 04:54 AM PST

Researchers have identified a distinct collection of bacteria found in the gut that may contribute to and predict the development of pulmonary arterial hypertension (PAH), according to new research published today in the American Heart Association's journal Hypertension.

PAH is a chronic and progressive disease in which the arteries that supply blood to the lungs are constricted, resulting in symptoms such as shortness of breath, heart palpitations, fatigue and others. In PAH, persistently high blood pressure in lung arteries makes the right side of the heart work too hard to pump blood, resulting in right-sided heart failure (inability of the heart to pump blood adequately). It is much less common than systemic blood pressure, which represents the force of blood moving through blood vessels throughout the entire body.

Everyone has a collection of bacteria in their gut -- known as microbiota -- that aid in digestion. The researchers found that having a specific microbiota profile in their gut predicted the presence of PAH with 83% accuracy.

"We showed for the first time that specific bacteria in the gut are present in people with PAH. While current PAH treatments focus on the lungs, looking at the lung/gut axis could open the door to new therapies centered in the digestive system," said Mohan Raizada, Ph.D., lead study author and distinguished professor in the department of physiology and functional genomics at the University of Florida College of Medicine in Gainesville, Fla.

For the study, stool samples were collected from 18 PAH patients and 12 people without a history of cardiopulmonary disease. The microbiota DNA from the stool samples were isolated and sequenced. The testing revealed a group of bacteria unique in the PAH patients that were associated with PAH.

This is the first link between a specific collection of bacteria and pulmonary arterial hypertension. However, it is not the first time that gut bacteria have been connected to medical conditions. A variety of different gut microbiota profiles have been linked to a variety of cardiovascular diseases including high blood pressure.

"We were very surprised to see such an association within a small group of study subjects," said Raizada. "It usually requires hundreds of patients to achieve such significance."

Gut microbiota are constantly changing, depending on what we eat, our environment and especially our genetic makeup. However, Raizada said the bacteria associated with PAH are unique and do not seem to change: "We believe these particular bacteria are constant."

If the results are validated in a larger study, the researchers said that the unique bacterial profile could help to diagnose PAH early, possibly replacing the invasive heart catheterization that is used today to diagnose the disease. Also, new types of treatment focused on altering the gut microbiome of PAH patients could be developed, providing new hope for halting the progression of the disease.

Another important question to be researched is how the gut bacteria impacts the lungs of PAH patients. "We do not know if and how gut bacteria and viruses make their way to the lungs," said Raizada. "Some studies have pointed to an increased incidence in intestinal leakage among people with pulmonary hypertension, which may allow some intestinal bacteria to get into the bloodstream and circulate to the lungs where they can cause inflammation and lead to vascular changes."

"There is still the question of whether the specific microbiota associated with PAH is the cause or the result of the disease, therefore, more research is needed," concluded Raizada.

Co-authors are: Seungbum Kim, Ph.D.; Katya Rigatto, Ph.D.; Marcelo Gazzana, M.D.-Ph.D.; Marli Knorst, M.D., Ph.D.; Elaine Richards, Ph.D.; Carl Pepine, M.D. Author disclosures are in the manuscript.

The study was funded by grants from the National Institutes of Health (NIH), the NIH National Center for Research Resources and the U.S. Department of Defense.

Aria CV Pulmonary Hypertension Acquires $31 Million for Feasibility Study - Diagnostic and Interventional Cardiology

Posted: 27 Feb 2020 11:43 AM PST

February 27, 2020 — Aria CV Inc. completed a $31 million Series B round of financing to fund its first clinical study in the United States for an implantable device to treat pulmonary arterial hypertension (PAH).

The funding will support an U.S. Food and Drug Administration (FDA) early feasibility investigational study designed to evaluate long term implants of the Aria CV Pulmonary Hypertension System (Aria CV PH System) in PAH patients. The Series B funding close comes just one week after the Aria CV PH System was granted Breakthrough Device Designation by the FDA, which is intended to expedite the FDA review and approval of designated devices that may provide more effective treatment of life-threatening diseases.

The financing was led by Xeraya Capital, a private equity and venture investor in life sciences that focuses on medical technologies, healthcare biotechnology, and bio-renewables. Also participating in the financing were Longview Ventures, Catalyst Health Ventures, BioStar Ventures, Cedar Point Capital, Frontcourt Group, and three strategic investors.

"We've worked with Aria CV for several years and are excited for the opportunity to lead this financing," said Jason Rushton, Partner at Xeraya Capital. "There is an unmet clinical need with patients suffering from pulmonary arterial hypertension, and we are impressed with the promising results the Aria CV PH System has demonstrated. We look forward to being a supportive partner."

PAH is a progressive and highly debilitating disease that often leads to heart failure. The implanted Aria CV PH System is designed to restore the benefits of a healthy, elastic pulmonary artery, which in turn reduces cardiac workload and enhances blood flow. This technology has the potential to improve both duration and quality of life as well as healthcare economics.

"Aria CV is now well positioned to drive our clinical research forward," said Dan Gladney, CEO and President of Aria CV. "We are grateful for this validation by our investors and remain committed to bringing this innovative treatment option to PAH patients."

As part of this financing, Jason Rushton will join Darshana Zaveri (Catalyst Health Ventures), Maria Berkman (Longview Ventures), Renee Masi (BioStar Ventures) and Dan Gladney, on the Board of Directors.

What is Pulmonary Hypertension?

Pulmonary hypertension is characterized by high blood pressure in the arteries of the lungs, a condition which causes increased workload on the heart, leading to right heart failure. In a common form of the disease, Pulmonary Arterial Hypertension affects mostly women often in the prime of life. Even with currently approved therapy, it is considered a deadly progressive disease.

Fore more information: www.ariacv.com

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