Evening dosing of blood pressure medication not better than morning dosing - European Society of Cardiology

Notes to editor

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This press release accompanies both a presentation and an ESC press conference at ESC Congress 2022. It does not necessarily reflect the opinion of the European Society of Cardiology.

Funding: The TIME study was funded by the British Heart Foundation (CS/14/1/30659) and supported by the British and Irish Hypertension Society and the National Institute for Health and Care Research in the UK.

Disclosures: TMM reports grants from the British and Irish Hypertension Society for the TIME pilot study, the British Heart Foundation and support from NIHR HTA for the submitted work. He has received funding for research from Menarini/Ipsen/Teijin and MSD and NIHR HTA funding outside the submitted work and personal income for consultancy from Novartis and AstraZeneca outside the submitted work and he is a trustee of the Scottish Heart Arterial Risk Prevention (SHARP) Society.

References and notes

1TIME will be discussed during:

2Hermida RC, Crespo JJ, Domínguez-Sardiña M, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. 2020;41:4565–4576.

3Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–3104.

4Hermida RC, Ayala DE. Chronotherapy with the angiotensin-converting enzyme inhibitor ramipril in essential hypertension improved blood pressure control with bedtime dosing. Hypertension. 2009;54:40-46.

5Ho CLB, Chowdhury EK, Doust J, et al. The effect of taking blood pressure lowering medication at night on cardiovascular disease risk. A systematic review. J Hum Hypertens. 2021;35:308–314.

6Rorie DA, Rogers A, Mackenzie IS, et al. Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study. BMJ Open. 2016;6:e010313.

About the European Society of Cardiology

The ESC brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people to live longer, healthier lives.

About ESC Congress 2022

It is the world's largest gathering of cardiovascular professionals, disseminating ground-breaking science both onsite in Barcelona and online – from 26 to 29 August. Explore the scientific programme. More information is available from the ESC Press Office at press@escardio.org.

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