Pulmonary Hypertension

Anything within that "hypertensive crisis" range warrants an immediate call to a doctor. "Typically, a blood pressure over 180 systolic is the range in which we start to worry about complications occurring in the immediate future," Dr. Lindley says. Certain symptoms are warning signs, too: "If you are having a headache, difficulty breathing, chest pain, or visual changes associated with an elevated blood pressure, you should call your doctor or go to the emergency room," Dr. Lindley urges. If you are pregnant or postpartum, a reading of over 140/90 warrants a call to your doctor or, if accompanied by symptoms, an ER visit, she adds.

Malignant hypertension is often diagnosed in the emergency room when a person seeks care for symptoms produced by severely high blood pressure causing damage to organ systems. The eyes, kidneys, and blood vessels are the organs most commonly affected. The clinical diagnosis of malignant hypertension (or hypertensive crisis) is based on the presence of high blood pressure (measured in both arms) at or above 180/120 millimeters of mercury (mmHg) and evidence of organ damage from a urinalysis, achest X-ray, a fundoscopic eye exam, and blood tests. This article will discuss how malignant hypertension is diagnosed, including physical examination, tests, and imaging. It will also discuss what other conditions will be considered. kali9 / Getty Images Self Checks/At-Home Testing If you have chronic high blood pressure, you may use a blood pressure monitor at home to track your readings. If you have a reading of 180/120 mmHg or higher, you shou...

Abstract The World Health Organization recently defined hypertension and type 2 diabetes (T2D) as modifiable comorbidities leading to dementia and Alzheimer's disease. In the United States (US), hypertension and T2D are health disparities, with higher prevalence seen for Black and Hispanic minority groups compared to the majority White population. We hypothesized that elevated prevalence of hypertension and T2D risk factors in Black and Hispanic groups may be associated with dementia disparities. We interrogated this hypothesis using a cross-sectional analysis of participant data from the All of Us (AoU) Research Program, a large observational cohort study of US residents. The specific objectives of our study were: (1) to compare the prevalence of dementia, hypertension, and T2D in the AoU cohort to previously reported prevalence values for the US population, (2) to investigate the association of hypertension, T2D, and race/ethnicity with dementia, and (3) to investigate whether r...

[unable to retrieve full-text content] Sleep apnea: What are the symptoms, causes and dangers? - explainer    The Jerusalem Post

Abstract Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell interactions in PAH, combining natural and induced bone morphogenetic protein receptor 2 (BMPR2) dysfunction with hypoxia to induce smooth muscle activation and proliferation, which is responsive to drug treatment. BMPR2- and oxygenation-specific changes in endothelial and smooth muscle gene expression, consistent with observations made in genomic and biochemical studies of PAH, enable insights into underlying disease pathways and mechanisms of drug response. The model captures key changes in the pulmonary endothelial phenotype that are essential for the induction of SMC remodelling, including a BMPR2-SOX17-prostacyclin signalling axis and offers an easily accessible approach for researchers to study pulmonary vascular remodelling and advance drug developmen...