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diastolic congestive heart failure :: Article Creator

The Difference Between Systolic Heart Failure And Diastolic Heart ...

Dr. Peter Alagona answers the question: 'Systolic vs. Diastolic Heart Failure?'

ByABC News

November 24, 2008, 11:42 AM

— -- Question: What is the difference between systolic heart failure and diastolic heart failure?

Answer: The heart has, basically, two large pumping chambers. One is the right ventricle which pumps blood into the lungs where the blood gets rid of carbon dioxide and picks up oxygen, and then the blood goes into the left side of the heart -- and the left ventricle, which is a much larger and stronger pumping chamber and pumps that fresh blood to the rest of the body. If either one of those chambers, or both chambers doesn't squeeze as well as it's supposed to, it can lead to a variety of different symptoms, and that's systolic heart failure -- right ventricular systolic failure, or left ventricular systolic failure.

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Diastolic failure is very different in that it affects mainly the left ventricle. When there are certain conditions -- and sometimes it just happens as we get older -- certain conditions where the ventricle doesn't relax and let blood fill it properly, in other words it's stiff or non-compliant, what happens in that circumstance is, the pressure of the blood in the ventricle goes up, it's reflected back into the left atrium -- the small chamber -- and then back in the lungs and even though it's not due to poor squeezing of the heart, the symptoms can be very similar, mainly breathlessness and fatigue.

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Office Management Of Patients With Diastolic Heart Failure

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Study Suggests How To Treat Diastolic Heart Failure - ScienceDaily

Research out of University Minnesota Medical School and published in the Journal of Clinical Investigation Insight uncovers what causes diastolic heart failure and how it can be treated.

In the article, "Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function," author Samuel Dudley, MD, PhD, Academic Chief of Cardiology at the University of Minnesota Medical School and his fellow researchers found that magnesium can be used to treat diastolic heart failure.

"We've found that cardiac mitochondrial oxidative stress can cause diastolic dysfunction. Since magnesium is an essential element for mitochondrial function, we decided to try the supplement as a treatment," explained Dudley. "It eliminated the poor heart relaxation that causes diastolic heart failure."

Obesity and diabetes are known risk factors for cardiovascular disease. Researchers discovered the magnesium supplement also improved the mitochondrial function and blood glucose in the subjects.

Patients with diastolic heart failure have a high morbidity, mortality, and healthcare costs. Patients with this condition have similar annual mortality to patients with systolic heart failure, and up until now there was no known specific treatments for this type of heart failure.

"This is an exciting step forward in the cardiovascular field," said Dudley, "Right now there are no specific treatments for patients with diastolic heart failure, but now we have a theory of why diastolic heart failure occurs and what we can do to get rid of it."

The next step is human trials. Dudley says this work could also open doors for answers for a related condition, atrial fibrillation.





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