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Small Cell Lung Cancer Treatments
Treatment for limited-stage small cell lung cancer (SCLC) often aims to cure the cancer. Extensive-stage SCLC treatment usually aims to prolong your life and reduce your symptoms.
Small cell lung cancer (SCLC) makes up 10–15% of all lung cancers. It tends to spread quickly and has a poor outlook.
In the United States, people diagnosed with SCLC from 2012–2018 lived at least 5 years about 7% as often as people without SCLC.
It's important to note that a person's individual outlook depends on the stage of cancer when it's diagnosed and how it responds to treatment. As newer or improved treatments are available, survival rates may continue to increase.
Some of the most common treatments for SCLC include:
Doctors are also trying many new treatments in clinical trials to see if they're more effective than current options.
Read on to learn more about what types of treatments are used to treat SCLC and when these treatments might be recommended.
SCLC is usually divided into two types: limited-stage or extensive-stage. It's classified as extensive-stage if it has spread:
About two-thirds of people have extensive-stage SCLC when they receive a diagnosis. Treatment for extensive-stage SCLC usually revolves around trying to extend your life and reduce symptoms.
Treatment for limited-stage SCLC often aims to cure the cancer.
Chemotherapy is used to treat limited- or extensive-stage SCLC, often in combination with other treatments. Chemotherapy drugs are usually given as an intravenous (IV) infusion or an injection. They're sometimes administered through larger IVs called central venous catheters.
For limited-stage SCLCTreatment for limited-stage SCLC may include:
Treatment for extensive-stage SCLC may include:
Doctors often administer a combination of chemotherapy drugs to target cancer cells in different ways. Some of the most common combinations in people with SCLC include:
Learn more about how chemotherapy is used to treat SCLC.
Immunotherapy medications stimulate your immune system to attack cancer cells. Doctors use a type of immunotherapy called immune checkpoint inhibitors to treat extensive-stage SCLC, often in combination with chemotherapy.
Immune checkpoint inhibitors work by blocking proteins made by cancer cells that allow them to hide from your immune cells. In the case of SCLC, doctors administer atezolizumab or durvalumab to block the protein PD-L1.
These drugs are usually given through an IV every 2–4 weeks.
Learn more about immunotherapy for lung cancer.
Radiation therapy is one of the most common treatments for SCLC. It involves aiming high energy rays at cancer cells to kill them. Doctors usually use external beam radiation therapy to treat lung cancer. This type of radiation therapy involves administering radiation from a machine outside of your body.
For limited-stage SCLCRadiation therapy may be used to treat limited-stage SCLC:
For extensive-stage disease, it may be administered:
Radiation as an initial SCLC treatment is usually given 1–2 times daily, 5 days per week for 3–7 weeks, according to the American Cancer Society (ACS). Cranial irradiation is usually administered for fewer than 3 weeks, the ACS says.
Research from 2021 estimates that in 10–20% of people with SCLC, the cancer has spread (metastasized) to the brain by the time of diagnosis, while 50–80% eventually develop metastasis during treatment.
Research from 2020 supports that cranial irradiation reduces the chances of cancer spreading to the brain, but it's less clear whether it improves survival.
Learn more about radiation therapy for lung cancer.
SCLC has usually spread too far to be treated surgically when it is diagnosed. Surgery may be used for limited-stage disease:
Surgery is usually performed under general anesthesia through a large incision in your back or chest. Doctors can use different types of surgery to treat lung cancer such as:
You may also have lymph nodes removed during any of these procedures.
Learn more about types of surgery for lung cancer.
Palliative procedures can help reduce your symptoms and increase your survival time. They don't aim to cure the cancer.
Palliative procedures include:
Learn more about the final stages of lung cancer.
Researchers are continuing to examine new treatments for SCLC in clinical trials. These treatments will become the new standard treatments if researchers find they're more effective than current options.
Some clinical trials currently underway include:
Learn more about clinical trials for SCLC.
SCLC is an aggressive form of lung cancer. It has usually already spread beyond the lungs when it's diagnosed.
Treatment for limited-stage SCLC often includes some combination of chemotherapy, surgery, and radiation therapy to try to cure the cancer.
Extensive-stage disease is usually treated with a combination of chemotherapy, radiation therapy, and immunotherapy.
September Is Pulmonary Fibrosis Awareness Month; What Is It?
September is Pulmonary Fibrosis Awareness Month. The condition causes lung scarring over time, resulting in horrible symptoms and low oxygen levels. It blocks the movement of oxygen from the lungs to the bloodstream.
Not too many people are familiar with the disease.
There's no cure, or specific cause, for this.
Cheri Riley of Greece was diagnosed in 2017. At the time, she had no idea what it was, and didn't even have symptoms.
Now, she's educating the public about it, with hopes to help others and maybe even save lives.
She enrolled in a clinical trial in January. It's her only hope for managing the disease, since the other two medications used to treat it don't work effectively on her body.
Every day, for four times a day, Cheri takes 12 breaths from a blue, ultrasonic nebulizer.
"My blue bong. It's easier to say 'I'm going to go hit my bong' than 'I have to do a treatment,'" she said, laughing.
Symptoms include dry cough, breathlessness and fatigue. But Cheri actually didn't develop those until later on.
"The disease has progressed to the point where I need to wear oxygen anytime I'm talking a lot, which I do a lot!" she said. "Or, if I'm out walking around, that exertion is too much. My lungs have scarred too much."
She's never been a smoker, and said no other health conditions contributed to this. It just crept up on her.
All it took was one doctor to listen closely during a routine check-up.
"He just said, 'let me take a listen to your lungs.' And he kept going back to one spot, and he instantly changed his demeanor."
Now she's raising awareness, because detection is hard. She said many people live with the disease and don't know it. Sometimes, doctors mistake it for other things.
This month, Cheri is encouraging others to raise awareness by wearing blue.
Buildings in Rochester were lit up blue over the weekend.
"And I knew that Rochester would come through," she said.
In the meantime, she's leaning into her support system, and enjoying her hobby of painting while retired.
She says she'll continue to speak out, until her last breath.
Cheri also spoke highly of her doctors at the University of Rochester Medical Center. The U of R said it is home to Upstate New York's only Pulmonary Fibrosis Foundation Care Center Network. A spokesperson said it's a prestigious designation among the top institutions across the country.
Cheri also works as an ambassador for the Pulmonary Fibrosis Foundation.
Two major support groups in Rochester support over 80 people.
To find support, visit here.
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