Evaluation and Management of Pulmonary Hypertension in ...
Global Idiopathic Pulmonary Fibrosis Management Market To Reach US$ 3649.90 Million By 2033: Focus On Developing New Drugs And TherapiesFMI
Idiopathic Pulmonary Fibrosis Management Market During the forecast period of 2023 to 2033, the global idiopathic pulmonary fibrosis management market is anticipated to grow at a CAGR of 1.5% from a market value of US$ 3145 million in 2023 to US$ 3649.90 million. The rising prevalence of the condition in men around the world is responsible for the expansion of the idiopathic pulmonary fibrosis management market. From 2018 to 2022, the market for treating idiopathic pulmonary fibrosis grew at a CAGR of 1%.
Several diagnostic methods exist for identifying IPF, and guidelines for diagnosis have been established. Tests such as pulmonary function tests are used to evaluate restrictive lung disease, which is indicated by decreased lung volume (specifically, reduced forced vital capacity, total lung capacity, and functional residual capacity) and decreased diffusion capacity.
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Furthermore, North America and Europe are two major regions contributing to the growth of the Idiopathic pulmonary fibrosis management market. This is owing to the high prevalence of the ailment in regions such as the Unites States of America and Germany. In addition, availability of various drugs along with innovative medication is shaping the landscape for the Idiopathic pulmonary fibrosis management market.
Key Takeaways from the Market Study:
"The presence of a wide range of drugs, as well as new and innovative medications, is influencing the market for managing Idiopathic pulmonary fibrosis." states an FMI analyst
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Competitive Landscape:
Key players in the idiopathic pulmonary fibrosis management market are
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Key Segments Profiled in the Idiopathic Pulmonary Fibrosis Management Industry Survey:
Drug Class:
Treatment:
Route of Administration:
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Author By:
Sabyasachi Ghosh (Associate Vice President at Future Market Insights, Inc.) holds over 12 years of experience in the Healthcare, Medical Devices, and Pharmaceutical industries. His curious and analytical nature helped him shape his career as a researcher.
Identifying key challenges faced by clients and devising robust, hypothesis-based solutions to empower them with strategic decision-making capabilities come naturally to him. His primary expertise lies in areas such as Market Entry and Expansion Strategy, Feasibility Studies, Competitive Intelligence, and Strategic Transformation.
Holding a degree in Microbiology, Sabyasachi has authored numerous publications and has been cited in journals, including The Journal of mHealth, ITN Online, and Spinal Surgery News.
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Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic pulmonary fibrosis (IPF) is a serious lung disease. When you breathe in, oxygen moves through tiny air sacs in your lungs and into your bloodstream. From there, it travels to your organs. IPF causes scar tissue to grow inside your lungs and makes it hard to breathe. It gets worse over time.
About 48,000 people get IPF each year in the United States.
IPF scar tissue is thick, like the scars you get on your skin after a cut. It slows oxygen flow from your lungs to your blood, which can keep your body from working as it should.
There's no cure for IPF. For most people, symptoms don't get better, but treatments can slow the damage to your lungs. Everyone's outlook is different. Some people will get worse quickly, while others can live 10 years or more after diagnosis. There are treatments to help you breathe easier and manage your symptoms. You may be able to have a lung transplant.
You can have idiopathic pulmonary fibrosis for a long time without noticing any symptoms.
What does IPF feel like? Your lungs each contain about 300 million tiny air sacs called alveoli that fill with oxygen every time you breathe. In healthy lungs, the walls of these air sacs are very thin, so that oxygen and carbon dioxide can easily pass through them.
When you have IPF, scar tissue forms on the air sac walls and in the spaces around them, making them thick and hard. This scarring makes it harder for air to pass in and out of the sacs. That's why you feel out of breath.
If you have IPF, you may have rapid, shallow breathing or a dry, hacking cough that doesn't go away. When a doctor listens to your breath sounds through a stethoscope, they may hear a crackling noise in your lungs.
After many years, the scarring in your lungs gets worse, and you might have:
Other symptoms of IPF include:
Doctors don't know what exactly causes IPF. "Idiopathic" means unexplained, and that's the term doctors use when they can't pinpoint a cause for your condition.
Researchers think certain things you breathed in are linked to IPF, such as wood dust or asbestos. They believe that the scarring is caused by something in the body that attacks the lungs over and over, but they don't know what or why.
IPF can run in families. Some people with the disease have one or more relatives who have it. In these cases, it's known as familial IPF.
Cigarette smoking is linked to IPF. So are some infections, such as the flu, Epstein-Barr virus (which causes mononucleosis), hepatitis, and herpes. These things may increase your risk of the disease, although they are not direct causes.
People with IPF may also have gastroesophageal reflux disease (GERD), also known as acid reflux. Scientists don't know if one disease causes the other, but they suspect that people with GERD may breathe tiny drops of stomach acid into their lungs, which can cause damage over time.
IPF is hard to tell apart from other lung diseases because it shares many of the same signs. It may take time and a lot of doctor visits to get the right diagnosis. If you have trouble breathing that doesn't get better, you'll probably need to see a pulmonologist, a doctor who treats lung problems.
The doctor will use a stethoscope to listen to your lungs. They might ask questions like:
Your doctor may ask you to get tests that look for damage in your lungs. They can also help rule out other diseases.
Some you can take in your doctor's office without any special preparation, but for others you'll need to go to a lab or hospital.
Chest scans. An X-ray lets your doctor see the structures inside your body. It may show shadows on your lungs that suggest scar tissue.
You may also need an HRCT scan (high-resolution computed tomography). It's a sharper and more detailed type of X-ray that can spot signs of IPF at an earlier stage.
Breathing test. Your doctor may use a device called a spirometer to measure how well your lungs are working.
You take a deep breath in and then blow as hard as you can into a tube connected to the device. You'll wear a clip on your nose so you can only breathe in and out of your mouth.
Pulse oximetry. Your doctor clips a small sensor to the tip of your finger or ear. It sends a painless beam of light through your skin to check the oxygen level in your arteries.
Blood test. It's used to check your oxygen and carbon dioxide levels.
Your doctor takes blood from an artery on the inside of your wrist, arm, or groin. It may be slightly more painful than a regular blood test, which takes a sample from your veins.
You may feel some discomfort. You'll need to sit calmly and keep pressure on the spot for a few minutes afterward to keep it from bleeding.
Skin test. Tuberculosis causes symptoms that are like IPF, so you may need a test to rule out this disease. Your doctor uses a tiny needle to inject a substance under the top layer of skin on your arm. This will form a small bubble, like a blister.
You'll need to see your doctor or lab technician 48 to 72 hours later to see if there's a reaction, which will look like a red, swollen bump.
Exercise test. It measures how well your lungs push oxygen through your bloodstream while you're moving around. You may have to walk on a treadmill or pedal a stationary bike while hooked up to devices that measure your heart rate, blood pressure, and how much oxygen is in your blood.
Lung biopsy. The best way for your doctor to diagnose IPF is to take small samples of tissue from your lungs and check them under a microscope for signs of scarring or other disease.
There are different ways to do it. Your doctor may put a needle through your chest, or they may put a long, thin tube through your mouth and down your throat.
For some biopsies, you'll only need "local anesthesia," which is medicine that numbs an area on your body. For others you'll need drugs that make you sleep while the procedure is done.
You may be asked to stop eating for 8 hours before the biopsy. Make sure to find out if there are any other ways you need to prepare.
Other lung tests. You might need to go to a hospital to get other exams done. For example, you could get a video-assisted thoracoscopy or bronchoscopy. Your doctor puts a tiny tube with a camera on the end through a cut in your chest or into your nose or mouth.
For a test called a bronchoalveolar lavage, your doctor injects salt water into your lungs to collect tissue samples.
Another option is a thoracotomy. Your doctor removes small pieces of lung tissue through a cut between your ribs.
You'll get medicine that puts you to sleep during these tests. Talk to your doctor about how you should prepare and what you should expect afterward.
You might want to ask:
Treatments for idiopathic pulmonary fibrosis won't cure the disease, but they can make it easier for you to breathe. Some may keep your lungs from getting worse quickly. Your doctor may suggest:
If your IPF scarring is severe, your doctor may suggest a lung transplant. Most people only think about doing this if other treatments aren't working.
Most people who get lung transplants are younger than 65. But if you're older and have no other serious medical problems, it may be an option for you.
It's a major operation. There aren't many lungs available from donors, so you'll go on a list to receive one. While you wait, avoid smoking, eat a healthy diet, do your breathing exercises, and stay as active as possible.
Once you get word that a donor has been found, you may have to go to the hospital quickly for your surgery, so make sure your doctor can reach you at all times.
You won't be awake during your surgery. Doctors put tubes into your mouth and windpipe that help you breathe while it's going on.
During the operation, your surgeon removes your lung and the blood vessels that connect it to your heart. They then attach your new lung to these blood vessels.
If you're getting two new lungs, you'll need a heart-lung bypass machine to pump oxygen into your blood during the surgery.
A single lung transplant takes 4-8 hours, and a double transplant takes 6-12 hours.
After surgery, you'll recover in the hospital for up to 3 weeks. You'll need to cough to clear fluid from your lungs. You'll also do breathing exercises to learn to take slow, deep breaths.
For 3 months after your surgery, your doctor will test your blood and lungs to make sure your body doesn't reject your new lung or you don't get any infections. You'll take medicines for the rest of your life to help prevent this from happening.
It can take weeks or months to recover. If you're thinking about getting a transplant, you'll need a lot of emotional support. Ask your doctor about support groups that have people facing the same concerns as you. Also find out about educational workshops that can explain what to expect before and after surgery.
Idiopathic pulmonary fibrosis is a serious disease. It will have a big effect on your life and your loved ones. To stay as healthy as possible, follow your treatment plan and see your doctor regularly to make sure your treatment is working.
Other things you can do to feel better include:
IPF life expectancy. How long you'll live with IPF depends on many things, including how old you were when you got your diagnosis, what stage your IPF is in, and how it's treated. Doctors don't know the average life expectancy. You may see online sources that say you'll live 3 to 5 years after diagnosis, but those numbers are outdated and don't take into treatment options you have now.
It can be hard to manage an illness like IPF. Remember that it's OK to ask a doctor, counselor, friend, or family member for help with any stress, sadness, or anger you may feel. Support groups are good places to talk to other people who are living with IPF or a similar condition. They can give you and your family advice and understanding.
The scar tissue in your lungs makes it hard for your body to get oxygen, which puts a strain on your other organs. IPF can raise your odds of getting other conditions, including:
Ask your doctor what you can do to lower your chances of having these problems. There may be treatments that can help with these conditions, too.
Everyone with IPF is different. For some, the disease gets worse quickly. For others, it can be a slow process in which their lungs stay the same for a long time. Talk to your doctor about your condition and what you can do to manage it.
Average survival is 3 to 5 years, but some people live much longer. A lung transplant can also change your life expectancy.
To learn more about IPF or find a support group in your area, visit the website of the Pulmonary Fibrosis Foundation.
Trouble Opening Your Mouth Properly? It May Be Oral Fibrosis: Know Its Symptoms And Causes
Do you ever find a person who is unable to open their mouth properly? They may be suffering from oral fibrosis, a disorder that affects the soft tissues of the oral cavity, resulting in the production of fibrous bands and decreased oral flexibility.
This disorder can affect a person's ability to execute basic oral tasks such as speaking, eating, and maintaining adequate oral hygiene. According to the World Health Organisation, in India, the prevalence of oral fibrosis ranges between 0.2% and 1.2%.
Symptoms of Oral Fibrosis Can't Able To Open Their Mouth Properly"One of the primary symptoms of oral fibrosis is a limited ability to open the mouth fully. As fibrous bands develop in the oral tissues, they restrict the normal range of motion, causing difficulty in activities like eating and speaking," said Dr Sanjay Chaudhary, MBBS, MD, VMMC, New Delhi.
Also read:Why Cystic Fibrosis Makes The Skin Salty?
Tightness or DiscomfortPeople with oral fibrosis often experience a sensation of tightness or discomfort in the affected areas. This can be particularly noticeable during jaw movements or when trying to open the mouth wider.
Fibrous bands can interfere with the proper functioning of the oral muscles, leading to difficulty in chewing and swallowing. This can result in nutritional deficiencies and weight loss over time.
Speech ImpairmentThe restricted movement of the oral structures can also affect speech. Pronouncing certain words and sounds may become challenging, impacting the individual's ability to communicate effectively.
Formation of Fibrous BandsVisible fibrous bands or bands that can be felt under the tongue or along the cheeks are a characteristic feature of oral fibrosis. These bands contribute to the tightening and reduced flexibility of the affected tissues.
Causes of Oral Fibrosis Tobacco and Betel Nut UseThe most common cause of oral fibrosis is the habitual use of tobacco and betel nut. Chewing tobacco or betel quid exposes the oral tissues to harmful substances that can lead to the development of fibrous bands over time.
Inadequate oral hygiene practices can contribute to the progression of oral fibrosis. Poor oral care can lead to chronic inflammation, creating an environment conducive to the development of fibrotic tissue.
Oral fibrosis is a condition that can significantly impact a person's quality of life. Recognising the symptoms early and seeking prompt medical attention is important for effective management. The key to preventing and treating oral fibrosis lies in addressing the underlying causes, particularly the cessation of tobacco and betel nut use.
Also read: Idiopathic Pulmonary Fibrosis Explained: All You Need To Know
People with oral fibrosis can regain optimal dental function and enhance their overall well-being with a comprehensive strategy that may involve lifestyle changes, physical therapy, and, in some circumstances, surgical intervention. Preventing the start or recurrence of this disorder requires regular dental check-ups and a dedication to proper oral hygiene.
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