Grade 1 Diastolic Dysfunction: Symptoms, Treatments
The Granulomatous Disorders
The granulomatous disorders are a group of conditions affecting a wide range of organ systems in the body. They are most commonly caused by infection and are characterized by multiple chronic inflammatory lesions. This is a field that has opened up substantially in recent years because of the explosion in new molecular biology techniques. This timely and comprehensive account is organized to include chapters focusing on causative agents as well as those addressing affected body systems. Highly illustrated throughout, this volume encompasses and integrates the very latest in science, pathology, and practical clinical advice available. Contributions by international authorities combine the expertise of both pathologists and clinicians. This book is sure to become a valuable resource to a very wide readership that includes infectious disease specialists, immunologists, pathologists, and general physicians.
"...I strongly recommend this exemplary volume to all physicians, even those who are unaware that they are interested in these remarkable bodily reactions that molecular biology is rescuing from a nosologic and descriptive catalog." Journal of the American Medical Association
"The Granulomatous Disorders, a beautifully illustrated and thoughtful textbook, provides a substantive overview of both infectious and idiopathic granulomatous disorders...This is a true reference book, with the chapters organized in such a way that they can be read independently of one another...In brief, this handsome, eminently readable book is an excellent reference for general clinicians, specialists, students, and scientists facing the challenge of understanding and treating the granulomatous disorders." The New England Journal of Medicine
"Professor D Geraint James is a global guru on sarcoidosis, and has made numerous contribitions to our knowledge of these disease and other granulomatosis...James and Zulma have created a new and important information sorce for a group of disease that are freqently difficult to diagnose and understanding...I urge all academic libraries to carry this book." Journal of Infectious Diseases
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× Product detailsPart I. Biology and Investigation of the Granuloma:1. Biology and immunology of the granuloma C. Agostini and G. Semenzato2. Classification of granulomatous disorders D. G. James and W. Jones Williams3. Imaging of granulomatous disorders J. Richenberg and J. Bomanji4. Electron microscopy of granulomas E. A. Sheffield5. The road from granuloma to fibrosis D. E. Elliot6. The GLUS syndrome H. Brincker and N. T. Pedersen7. Experimental skin granulomas W. L. Epstein and K. FukuyamaPart II. Infectious Granulomas:8. Granulomatous infections: an overview A. Zumla and D. G. James9. Microbiological diagnosis of granulomatous infections S. Gillespie10. Tuberculosis A. Zumla, G. Rook, P. Mwaba and S. Lucas11. Human disease caused by Mycobacterium Bovis and Bacillus Calmette Guérin (BCG) J. Grange12. Leprosy A. Zumla, A. Ustianowski, S. Lucas and L. Munthali13. Non-tuberculous mycobacterial infections M. Wansbrough-Jones and D. Banerjee14. Helminth infestations G. Cook15. Leishmaniasis R. Baker, P. Chiodini and P. Kaye16. Fungal infections D. W. Denning and G. E. Wilson17. Toxoplasmosis R. Holliman, J. Johnson and M. Burke18. Sexually transmitted diseases R. Baker, B. Peters and M. GriffithsPart III. Granulomas and Disease:19. Sarcoidosis D. G. James and W. Jones Williams20. Idiopathic systemic granulomatous vasculitis J. T. Lie21. Berylliosis C. Saltini, T. N. Markham and W. Jones Williams22. Bone marrow granulomas B. Bain23. Granuloma and cancer F. K. Rømer24. Pulmonary angiitis and granulomatosis R. A. DeRemee, R. C. Anton and P. T. Cagle25. Granulomas in primary immunodeficiency A. D. B. Webster and P. AmlotPart IV. Granulomas and Body Systems:26. Cardiovascular disorders A. S. Tierstein27. Respiratory granulomatoses D. G. James and W. Jones Williams28. Granulomatous liver disorders S. Sherlock29. Granulomatous disorders of the nervous system O. P. Sharma and V. Oksanen30. Crohn's disease and other granulomatous diseases of the intestines J. V. Weinstock and D. E. Elliot31. Lymphoreticular system D. G. James and W. Jones Williams32. Granulomatous disorders of the female genital tract L. Regan and E. Cela33. Skin granulomas in clinical practice S. Chopra and F. Vega-López34. Kidney disorders B. I. Hoffbrand, H. Lachmann and M. Griffiths35. Granulomatous disorders of the eye A. S. Dunlop, P. Luthert and S. Lightman36. Paediatric granulomas R. J. Fitzgerald and P. Campbell.
EditorsD. Geraint James, Royal Free Hospital School of Medicine, University of London
A. Zumla, University College London Medical School
ContributorsC. Agostini, G. Semenzato, D. G. James, W. Jones Williams, J. Richenberg, J. Bomanji, E. A. Sheffield, D. E. Elliot, H. Brincker, N. T. Pedersen, W. L. Epstein, K. Fukuyama, A. Zumla, S. Gillespie, G. Rook, P. Mwaba, S. Lucas, J. Grange, A. Ustianowski, L. Munthali, M. Wansbrough-Jones, D. Banerjee, G. Cook, R. Baker, P. Chiodini, P. Kaye, D. W. Denning, G. E. Wilson, R. Holliman, J. Johnson, M. Burke, B. Peters, M. Griffiths, J. T. Lie, C. Saltini, T. N. Markham, B. Bain, F. K. Rømer, R. A. DeRemee, R. C. Anton, P. T. Cagle, A. D. B. Webster, P. Amlot, A. S. Tierstein, S. Sherlock, O. P. Sharma, V. Oksanen, J. V. Weinstock, L. Regan, E. Cela, S. Chopra, F. Vega-López, B. I. Hoffbrand, H. Lachmann, A. S. Dunlop, P. Luthert, S. Lightman, R. J. Fitzgerald, P. Campbell
Lung Disease News
Sep. 12, 2023 — An international team of researchers has demonstrated that a combination of inhibitors may suppress tumor growth and prevent relapse in patients with certain cancers, including head and neck squamous ...
Sep. 7, 2023 — Women exposed to air pollution give birth to smaller babies, according to new research. The research also shows that women living in greener areas give birth to bigger babies and this may help ...
Sep. 7, 2023 — Researchers reveal for the first time that high blood sugar levels in type 2 diabetes can play a causal role in lung ...
Sep. 5, 2023 — A new study has shown that a subtype of avian flu virus, endemic in poultry farms in China, is undergoing mutational changes, which could increase the risk of the disease being passed on to ...
Aug. 30, 2023 — Fresh discoveries about a type of immune cells could give lung cancer patients a more accurate prognosis and better identify who will benefit from immunotherapies. Researchers found that the location ...
Aug. 25, 2023 — High levels of some minerals and metals in environmental water supplies may increase the risk of nontuberculous mycobacteria (NTM) pulmonary infections in people with cystic fibrosis, according to a ...
Aug. 24, 2023 — Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary ...
Aug. 16, 2023 — Researchers have found that molecules in vegetables like broccoli or cauliflower help to maintain a healthy barrier in the lung and ease ...
Aug. 11, 2023 — Yoga and breathing control practices, in combination with aerobic training, are particularly key exercises for asthmatic people seeking to improve their lung function, a new peer-reviewed study ...
Aug. 9, 2023 — New findings may lead to relapse-free treatment for a sizeable subgroup of lung cancer patients. In a study in mice, scientists have identified a biomarker that may help physicians select lung cancer ...
Aug. 8, 2023 — Overly active immune cells are often behind lung damage in diseases such as Covid-19. Researchers have developed an RNA agent for a lung spray that slows the activity of these cells, known as ...
July 25, 2023 — Having a food allergy as a baby is linked to asthma and reduced lung function later in childhood, according to a new ...
July 20, 2023 — Omega-3 fatty acids, which are abundant in fish and fish oil supplements, appear promising for maintaining lung health, according to new evidence from a large, multi-faceted study in healthy adults. ...
July 7, 2023 — The mucus in the airways is not as sticky, inflammation in the lungs significantly reduced: Triple combination therapy can achieve these positive, lasting effects in patients with cystic fibrosis ...
June 22, 2023 — Small-cell lung cancer is a particularly aggressive type of tumor with a consistently high mortality rate. In recent years, the research of scientists has significantly contributed to a better ...
June 8, 2023 — The largest and most comprehensive cell map of the human lung has been completed. The Human Lung Cell Atlas reveals the great diversity of cell types in the lung and shows key differences between ...
June 1, 2023 — Researchers have collaborated to refine a cell culture technology platform that grows genetically identical lung buds from human embryonic stem ...
May 24, 2023 — A new study has shown that human T cells have an important role to play in controlling ...
Apr. 21, 2023 — Storing donor lungs for transplant at 10 degrees Celsius markedly increases the length of time the organ can live outside the body according to new ...
Mar. 31, 2023 — A new type of nanoparticle can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins. Researchers hope to use them to develop new treatments for cystic fibrosis ...
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Lung Disease: Facts You Need To Know
In August 2019, Angie Abad went to the ER to be treated for a respiratory infection. Medical workers there tested her and prescribed meds, but Abad "never really felt right after that."
After a second respiratory infection and growing problems with breathing, her local hospital still couldn't put a finger on the problem. Finally, a more specialized hospital nearby ran more breathing and lung tests and diagnosed her with the lung disease COPD.
But the diagnosis and the treatments that followed -- including extra oxygen, a nebulizer, and an inhaler -- still left Abad, who is 50 and lives in Denver, without answers to mounting questions. She felt even worse about her condition because she'd watched her father die of the same disease 8 years before.
"I didn't know any questions to ask my pulmonologist," Abad says. "I've just taken the meds she's put me on and left it at that. No one has told me what to expect, possible side effects of meds, or [other] things I would experience."
She didn't find much more support from friends, either. "When you tell people about your diagnosis of COPD, they say, 'Oh,'" she says. "There isn't enough awareness. People don't understand the daily struggles of this disease."
David Mannino, MD, a pulmonologist in Lexington, KY, and the medical director and co-founder of the COPD Foundation, agrees that too many people with lung disease remain in the dark after diagnosis.
On top of people not knowing what questions to ask, "One of the challenges we always seem to have is, a lot of people think it's some type of death sentence. It's not," he says. Mannino has been treating some COPD patients for 15 to 20 years.
Another factor is people with COPD perhaps not knowing they can seek -- and deserve -- support. "A lot of people go into it with shame and blame," Mannino says. For example, smokers might react to their diagnosis by realizing their habit helped set the stage to get the disease. But the guilt should stop there.
"You are dealing with something that is incredibly addicting," Mannino says. "And it's not that way by accident," he says, referring to tobacco companies' longtime knowledge of the harms the substance causes. Even if you can trace the cause of COPD to your lifestyle, this is a time to be gentle on yourself.
Abad filled the many gaps in her grasp of her medical condition "through research, COPD groups, and personal experience."
Her journey has turned up many points she feels are key for people with lung disease to cover with their doctors, answers she wished she'd had all along. They include:
A special question for her was if altitude makes COPD worse. She's newly moved to Denver, which clocks in at 1 mile above sea level. A higher altitude can tax your breathing, mainly at first.
Mannino says he often hears people who have moderate to severe COPD say they wished they'd gone to a pulmonary rehab center or other educational program years before. In these programs, people learn earlier rather than later how to, for example, stretch and breathe properly. They're also taught to fend off panic attacks and times when they can't catch their breath with methods like pursed lip breathing. It's a technique in which you inhale through your nose and breathe out through puckered lips.
Some exercises can actually be fun, Mannino notes, such as playing the harmonica. The higher notes provide ideal breathing workouts.
Such programs also teach people with lung disease how to use meds and lung devices the right way. "Patients learn too late that different respiratory meds require different techniques as to how to use them correctly," Mannino says. "Even physicians might not know how to use these correctly."
However, "the number of rehab programs for COPD are far too few," especially in rural places, he says. The COVID-19 pandemic and its limits on people getting together for anything "nonessential" has made it even harder to get into these programs. Doctors also expect some people who've had COVID will need pulmonary rehab, which will put more strain on the system.
Technology has made it simple for anyone to access disease support, though. A number of lung disease management apps have sprung up, including a free app through the COPD Foundation called the COPD Pocket Consultant Guide. It's designed for people with the disease and their families. You can download it from the foundation website or Google Play.
The app includes links for the right way to use meds, easy ways to track your schedules, and other useful tools rehab programs cover. "You can even print out [info] sheets to give the doctor" to prompt helpful questions and start talks that can sharpen your insights into your condition, Mannino says.
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